Inhibitors of stereoidogenesis

Inhibitor of Steroid Sulfatase (STS) Inhibitor of 17β-Hydroxysteroid Dehydrogenase (17β-HSD) type 3 Inhibitor of 17β-Hydroxysteroid Dehydrogenase (17β-HSD) type 1
  1. ID : DP-LCC-1913
  2. Structure :
  3. Activity (steroid sulfatase inhibition) :
    IC50 = 0.024 ± 0.008 nM for the transformation of estrone sulfate into estrone by an homogenate of HEK-293 cells overexpressing STS. DP-LCC-1913 efficiently blocks (s.c and p.o) uterine growth induced by estrone sulfate in ovariectomized mouse model at 100µg/day.
  4. Solubility :
    Ethanol, dimethylsulfoxide and organic solvents.
  5. HPLC Purity : 99.5%
  6. Prices* :
    2 mg (1000$ USD)
    5 mg (2000$ USD)
    10 mg (3000$ USD)
    >10 mg (contact us for quotation)
    *Discount (50%) is offered to academic researcher in a collaboration agreement.
  7. References :
    Ciobanu, L.C.; Luu-The V.; Martel, C.; Labrie, F.; Poirier D. Cancer Res., 63, (2003), 6442-6446.
  1. ID : DP-BTN-2
  2. Structure :
  3. Activity (17β-HSD type 3 inhibition) :
    IC50 = 67 ± 6 nM for the transformation of 4-androstene-3,17-dione into testosterone by an homogenate of HEK-293 cells overexpressing 17β-HSD type 3. No androgenic on Shionogi (AR+) cells.
  4. Solubility :
    Ethanol, dimethylsulfoxide and organic solvents.
  5. HPLC Purity :
  6. Prices* :
    2 mg (1000$ USD)
    5 mg (2000$ USD)
    10 mg (3000$ USD)
    >10 mg (contact us for quotation)
    *Discount (50%) is offered to academic researcher in a collaboration agreement.
  7. References :
    (a) Tchédam-Ngatcha, B.; Laplante, Y.; Labrie, F.; Luu-The, V.; Poirier, D. Mol. Cell. Endocrinol., (2006), 248, 225-232.
    (b) Tchedam-Ngatcha, B.; Luu-The, V.; Labrie, F.; Poirier, D. J. Med. Chem., (2005), 48, 5257-5268.
  1. ID : DP-CC-156
  2. Structure :
  3. Activity (17β-HSD type 1 inhibition) :
    IC50 = 44 ± 7 nM for the transformation of estrone into estradiol in the intact T-47D breast cancer cells (expressing 17β-HSD type 1).
  4. Solubility :
    Ethanol, dimethylsulfoxide, methanol, ethyl acetate.
  5. HPLC Purity : 99.1%
  6. Prices* :
    2 mg (1000$ USD)
    5 mg (2000$ USD)
    10 mg (3000$ USD)
    >10 mg (contact us for quotation)
    *Discount (50%) is offered to academic researcher in a collaboration agreement.
  7. References :
    (a) Laplante, Y.; Rancourt, C.; Poirier, D. Molecular and Cellular Endocrynology (2009), 3001 (1-2), 146-153
    (b) Laplante, Y.; Cadot, C.; Fournier, M.-A.; Poirier, D. Bioorg. Med. Chem. (2008), 16 (4), 1849-1860.

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